What does Soce mean?

Sommario:

1. What does Soce mean?
2. What is Soce calcium?
3. What does ORAI1 stand for?
4. Is ORAI1 a CRAC channel?
5. What is ORAI in biology?
6. Is ORAI a CRAC channel?

What does Soce mean?

archaic. : comrades, friends —used as a term of address.

What is Soce calcium?

Store-operated calcium entry (SOCE) is the process by which the emptying of ER calcium stores causes influx of calcium across the plasma membrane. This signaling pathway is widespread in eukaryotic cells and is involved in a host of cellular functions ranging from gene expression to regulation of proliferation.

What does ORAI1 stand for?

ORAI calcium release-activated calcium modulator 1

ORAI1
Available structures PDB Ortholog search: PDBe RCSB showList of PDB id codes
Identifiers
Aliases	ORAI1, CRACM1, IMD9, ORAT1, TAM2, TMEM142A, ORAI calcium release-activated calcium modulator 1
External IDs	OMIM: 6102542 HomoloGene: 13117 GeneCards: ORAI1

Is ORAI1 a CRAC channel?

E106D and E190Q substitutions in transmembrane helices 1 and 3, respectively, diminish Ca2+ influx, increase current carried by monovalent cations, and render the channel permeable to Cs+. These changes in ion selectivity provide strong evidence that Orai1 is a pore subunit of the CRAC channel.

What is ORAI in biology?

Calcium release-activated calcium channel protein 1 is a calcium selective ion channel that in humans is encoded by the ORAI1 gene. ... Orai proteins share no homology with any other ion channel family of any other known proteins. They have 4 transmembrane domains and form hexamers.

Is ORAI a CRAC channel?

CRAC channels are formed by members of the recently discovered Orai protein family, with previous studies indicating that the functional channel is formed by a tetramer of Orai subunits.